Daily evidence update
DAILY UPDATE ·
Probiotics did not improve psoriatic arthritis response
A 12-week randomized placebo-controlled trial found no statistically supported improvement in the primary treatment-response outcome.
- Papers
- 29
- Within scope
- 27
- Primary human interventions
- 1
- Studies included
- 1
Daily microbiome literature · 5 October 2026
Today's literature: 29 papers; 1 primary human intervention.
6 animal and in-vitro studies read, not shown.
Multispecies probiotic and psoriatic arthritis
A 12-week randomized double-blind placebo-controlled trial included 66 adults with psoriatic arthritis receiving a multispecies probiotic or placebo. Treatment response occurred in 43% of the probiotic group and 65% of the placebo group (odds ratio zero point four; 95% CI 0.13–1.18; p = 0.167). The primary result did not show a statistically supported benefit. Secondary clinical, permeability, immune-cell and stool-microbiome outcomes also showed no between-group differences. The abstract did not report the probiotic dose or strain identifiers. No serious adverse events related to the study product were reported.
Efficacy and safety of probiotic supplementation in psoriatic arthritis - a randomized controlled trial.
STUDY DESCRIPTORRCT
Model: human participants.MODEL · HUMAN PARTICIPANTS
INTERPRETATION BOUNDARY
Data from human participants do not by themselves establish applicability beyond the population and outcomes studied. The confidence interval was wide and included both no effect and potentially meaningful effects; the abstract did not report the probiotic dose or strain identifiers.
SOURCEPMID 42832303
ISSUE INTERPRETATION BOUNDARY
One primary human intervention was included from 29 papers found; 27 were within scope and 18 were reviewed.